Introduction. Current treatment strategies for osteoporotic vertebral compression fractures (VCFs) focus on cement-associated\nsolutions. Complications associated with cement application are leakage, embolism, adjacent fractures, and compromise in bony\nhealing. This study comprises a validatedVCFmodel in osteoporotic sheep in order to (1) evaluate a newcementless fracture fixation\ntechnique using titaniummesh implants (TMIs) and (2) demonstrate the healing capabilities in osteoporoticVCFs. Methods. Twelve\n5-year-old Merino sheep received ovariectomy, corticosteroid injections, and a calcium/phosphorus/vitamin D-deficient diet for\nosteoporosis induction. Standardized VCFs (type AO A3.1) were created, reduced, and fixed using intravertebral TMIs. Randomly\nadditional autologous spongiosa grafting (G1) or no augmentation was performed (G2,
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